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x86-64 (also known as x64, x86_64, AMD64, and Intel 64) is a 64-bit version of the x86 instruction set, first released in 1999.

Snippet from Wikipedia: X86-64

x86-64 (also known as x64, x86_64, AMD64, and Intel 64) is a 64-bit version of the x86 instruction set, first announced in 1999. It introduced two new modes of operation, 64-bit mode and compatibility mode, along with a new 4-level paging mode.

With 64-bit mode and the new paging mode, it supports vastly larger amounts of virtual memory and physical memory than was possible on its 32-bit predecessors, allowing programs to store larger amounts of data in memory. x86-64 also expands general-purpose registers to 64-bit, and expands the number of them from 8 (some of which had limited or fixed functionality, e.g. for stack management) to 16 (fully general), and provides numerous other enhancements. Floating-point arithmetic is supported via mandatory SSE2-like instructions, and x87/MMX style registers are generally not used (but still available even in 64-bit mode); instead, a set of 16 vector registers, 128 bits each, is used. (Each register can store one or two double-precision numbers or one to four single-precision numbers, or various integer formats.) In 64-bit mode, instructions are modified to support 64-bit operands and 64-bit addressing mode.

The compatibility mode defined in the architecture allows 16-bit and 32-bit user applications to run unmodified, coexisting with 64-bit applications if the 64-bit operating system supports them. As the full x86 16-bit and 32-bit instruction sets remain implemented in hardware without any intervening emulation, these older executables can run with little or no performance penalty, while newer or modified applications can take advantage of new features of the processor design to achieve performance improvements. Also, a processor supporting x86-64 still powers on in real mode for full backward compatibility with the 8086, as x86 processors supporting protected mode have done since the 80286.

The original specification, created by AMD and released in 2000, has been implemented by AMD, Intel, and VIA. The AMD K8 microarchitecture, in the Opteron and Athlon 64 processors, was the first to implement it. This was the first significant addition to the x86 architecture designed by a company other than Intel. Intel was forced to follow suit and introduced a modified NetBurst family which was software-compatible with AMD's specification. VIA Technologies introduced x86-64 in their VIA Isaiah architecture, with the VIA Nano.

The x86-64 architecture was quickly adopted for desktop and laptop personal computers and servers which were commonly configured for 16 GiB (gibibytes) of memory or more. It has effectively replaced the discontinued Intel Itanium architecture (formerly IA-64), which was originally intended to replace the x86 architecture. x86-64 and Itanium are not compatible on the native instruction set level, and operating systems and applications compiled for one architecture cannot be run on the other natively.

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